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In bioinformatics the PANTHER (Protein ANalysis THrough Evolutionary Relationships) classification system is a large curated biological database of gene/protein families and their functionally related subfamilies that can be used to classify and identify the function of gene products. PANTHER is part of the Gene Ontology Reference Genome Project designed to classify proteins and their genes for high-throughput analysis. The project consists of both manual curation and bioinformatics algorithms. Proteins are classified according to family (and subfamily), molecular function, biological process and pathway. It is one of the databases feeding into the European Bioinformatics Institute's InterPro database. -- Application of PANTHER -- The most important application of PANTHER is to accurately infer the function of uncharacterized genes from any organism based on their evolutionary relationships to genes with known functions.〔 By combining gene function, ontology, pathways and statistical analysis tools, PANTHER enables biologists to analyze large-scale, genome-wide data obtained from the current advance technology including: sequencing, proteomics or gene expression experiments. Shortly, using the data and tools on the PANTHER, users will be able to: * Obtain information about a particular gene of interest. * Discover protein families and subfamilies, pathways, biological processes, molecular functions and cellular components. * Create lists of genes related to a particular protein family/subfamily, molecular function, biological process or pathway. * Analyze lists of genes, proteins or transcripts. == PANTHER history == * 1998:Project was launched at Molecular Application Group. * 1999:Acquired by Celera Genomics. * 2000:PANTHER 1 released in Celera Discovery Systems (CDS). * 2001: PANTHER 2 released, which is used in the annotationon of the first published human genome Celera. * 2002: PANTHER 3 released. PANTHER annotations are integrated in FlyBase. Moved to ABI. * 2003: PANTHER 4 released with the public release of PANTHER Classification System. * 2005: PANTHER 5 released with PANTHER Pathway and analysis tool. Establish collaboration with InterPro. * 2006: PANTHER 6 released. Move to SRI. * 2010: PANTHER 7 released. * 2011: Move to USC. * 2012: PANTHER 8 released. * 2014: PANTHER 9 released.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「PANTHER」の詳細全文を読む スポンサード リンク
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